Squidbillies centers around a family of redneck squids living in Georgia. The main characters are Early Cuyler, a recent ex-con released to take care of his teenage son; Rusty, Early's son with the town prostitute; and Lil, Early's sister who took care of Rusty while Early was in jail but later lost him to the state when a meth lab was found in her home. See? Hilarious. Oh, and they also live with their grandmother (great-grandmother for Rusty), Granny Cuyler.
My Squidbillies epiphany came with one episode: "The Original Gator Hator," which features the star of Lil's litter of squids with an unknown man, that star being Hershel Walker Cuyler Them Dawgs Is Hell Don’t They (I call him "Baby H" for short).
Baby Hershel's little "woo!" gets me everytime. D'awwww.
Some background on Baby H:

- Partially named after mixed martial artist, former football player, and Georgia native Herschel Walker
- Unofficially adopted by his Uncle Early, whose yell of destruction he adorably imitates
- Impresses Uncle Early with his incredible acts of violence (i.e. killing off the rest of his siblings after Early takes the litter to see Saw 3)
- Shaped like a molar, slightly cock-eyed, fond of giant hats